Biomedical & Human Health

Biomedical & Human Health

RELATED PROJECTS

NMC Health and Biomedical Vaccine Research Los Alamos

Bette Korber, NMC Research Scientist, LANL Affiliate
Jame Theiler, NMC Research Scientist


This project is the continuation of a project we started with the Bill and Melinda Gates Foundation, initially funded in Feb. 2021 to extend our HIV collaboration with the Barouch Laboratory at Harvard and begin to develop a SARS-CoV-2 vaccine approach that could potentially better handle the evolving pandemic and novel SARS-CoV-2 variants as they arose. The current proposal would enable building on that work to conduct a proof-of-concept vaccine study with our initial designs and would allow us to help analyze the results of an initial primate study conducted at Harvard, as well as and to conduct iterative designs based on what we learn and how the virus continues to evolve. We aim to develop and evaluate Epigraph based pan-SARS-CoV-2 vaccines and evaluate candidate pan-sarbecovirus vaccines. This project is sponsored by the Bill and Melinda Gates Foundation.
Biomedical Image

Dr. Goldberg, Emma – LANL/NMC Research Scientist, Joint Appointee
Ethan Romero-Severson – LANL/NMC Research Scientist


Pandemics pose a global challenge in need of international, collaborative solutions. A major focus of the Center is on capacity building, workflow scalability, and dissemination across borders. In collaboration with Project ECHO and the virtual network Museums and Emerging Pathogens in the Americas (MEPA), the Center will expand development of wildlife sampling strategies and a comprehensive, decentralized network of local biorepositories for pathogen surveillance. We will focus on changing environmental interfaces and use the archives to examine changes in host reservoirs and pathogen communities across space and time and predict conditions that stimulate pathogen emergence. Interoperable, open data will ensure that actionable products of our Center are available and accessible to diverse stakeholders ranging from local communities to international public health agencies. New capacities for visualization, informatics interpretation, and translation emanate from development of fast, affordable, and scalable sequencing and bioinformatic technologies allowing methods of pathogen detection, discovery, and monitoring that foster global pathogen surveillance. Through the collaborative network MEPA, we will promote international adoption of strategic approaches and technologies by offering a multicomponent virtual education, capacity building, and collaborative problem-solving series for biorepositories in the Americas. Through this necessary foundation, CEPPI codifies standardized exploration of biodiversity and builds connections with local communities, sequencing and bioinformatic facilities, and public health and natural resource agencies.

This project is sponsored by the National Science Foundation (NSF) via a UNM/UNM led project.

HIV Vaccine - New Mexico Consortium, Los Alamos, New Mexico

Bette Korber, NMC Research Scientist, LANL Affiliate
Jame Theiler, NMC Research Scientist


Signature analysis for two epitope regions, V2-apex and FP epitopes, based on neutralizing antibody responses to the much more contemporary viruses that were sampled through recent clinical efficacy trails conducted by the HVTN. On the basis of this new analyses we will update the V2 vaccine design, and we will also finalize a FP vaccine design. This project is sponsored by the Bill and Melinda Gates Foundation.

Emerging Infectious Diseases - New Mexico Consortium, Los Alamos, New Mexico

Kshitij Wagh, NMC Affiliate Scientist, LANL Staff Scientist


This program is in collaboration with Dr. David Montefiori at Duke University. Our role is to assist in the analysis of broadly neutralizing antibodies and antibodies with other functionalities against HIV variants,design reagent panels for global vaccine trials, and to help develop and analyze antibody reagents for therapy and prevention. This project is sponsored by the Bill and Melinda Gates Foundation.

PAST PROJECTS

Phenix Protein Research - New Mexico Consortium, Los Alamos, New Mexico
  • Phenix: Integrated Algorithms for High Quality Models from Crystallographic and cryo-EM Data
  • Development of Spread-Deficient HCMV/HIV Vectors for a Prophylactic HIV Vaccine
  • CECI Supplement, HTVN106
  • Spartina Biotechnologies: Developing SIREN™, an Antiviral Therapeutic That Blocks Replication of Viruses and Activates the Immune Response Within the Patient.