Biomedical & Human Health

Biomedical & Human Health

RELATED PROJECTS

NMC Health and Biomedical Vaccine Research Los Alamos

Bette Korber, NMC Research Scientist, LANL Affiliate
Jame Theiler, NMC Research Scientist


This project is the continuation of a project we started with the Bill and Melinda Gates Foundation, initially funded in Feb. 2021 to extend our HIV collaboration with the Barouch Laboratory at Harvard and begin to develop a SARS-CoV-2 vaccine approach that could potentially better handle the evolving pandemic and novel SARS-CoV-2 variants as they arose. The current proposal would enable building on that work to conduct a proof-of-concept vaccine study with our initial designs and would allow us to help analyze the results of an initial primate study conducted at Harvard, as well as and to conduct iterative designs based on what we learn and how the virus continues to evolve. We aim to develop and evaluate Epigraph based pan-SARS-CoV-2 vaccines and evaluate candidate pan-sarbecovirus vaccines. This project is sponsored by the Bill and Melinda Gates Foundation.
HIV Vaccine - New Mexico Consortium, Los Alamos, New Mexico

Bette Korber, NMC Research Scientist, LANL Affiliate
Jame Theiler, NMC Research Scientist


Signature analysis for two epitope regions, V2-apex and FP epitopes, based on neutralizing antibody responses to the much more contemporary viruses that were sampled through recent clinical efficacy trails conducted by the HVTN. On the basis of this new analyses we will update the V2 vaccine design, and we will also finalize a FP vaccine design. This project is sponsored by the Bill and Melinda Gates Foundation.

Emerging Infectious Diseases - New Mexico Consortium, Los Alamos, New Mexico

Kshitij Wagh, NMC Affiliate Scientist, LANL Staff Scientist


This program is in collaboration with Dr. David Montefiori at Duke University. Our role is to assist in the analysis of broadly neutralizing antibodies and antibodies with other functionalities against HIV variants,design reagent panels for global vaccine trials, and to help develop and analyze antibody reagents for therapy and prevention. This project is sponsored by the Bill and Melinda Gates Foundation.

PAST PROJECTS

Phenix Protein Research - New Mexico Consortium, Los Alamos, New Mexico
  • Phenix: Integrated Algorithms for High Quality Models from Crystallographic and cryo-EM Data
  • Development of Spread-Deficient HCMV/HIV Vectors for a Prophylactic HIV Vaccine
  • CECI Supplement, HTVN106
  • Spartina Biotechnologies: Developing SIREN™, an Antiviral Therapeutic That Blocks Replication of Viruses and Activates the Immune Response Within the Patient.